Below is the 2008 CMU Graduation Speech written by Pausch. I found it very powerful.
I assure you I've done a lot of really stupid things, and none of them bother me. All the mistakes, and all the dopey things, and all the times I was embarrassed — they don't matter. What matters is that I can kind of look back and say: pretty much any chance I had to do something cool I tried to grab for it — and that's where my solace comes from.
It is not the things we do in life that we regret on our death bed. It is the things we do not. Find your passion and follow it. And if there is anything that I have learned in life, you will not find that passion in things. And you will not find that passion in money. Because the more things and the more money you have, the more you will just look around and use that as the metric — and there will always be someone with more. Your passion must come from the things that fuel you from the inside. That passion will be grounded in people. It will be grounded in the relationships you have with people and what they think of you when your time comes.